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KMID : 0358420090520090903
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 9 p.903 ~ p.910
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Clinical characteristics and perinatal outcomes of fetal omphalocele
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Hyun Min-Kyung
Shim Jae-Yoon
Won Hye-Sung
Lee Pil-Ryang
Kim Ahm
Ju Da-Hye
Na Sung-Hun
Cha Kyung-Hee
Park Sun-Kyung
Lim So-Hee
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Abstract
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Objective: The purpose of this study is to describe the clinical characteristics and perinatal outcomes of fetuses with omphalocele.
Methods: The study enrolled all fetuses diagnosed prenatally with omphalocele at a single institution, from August 1996 to April 2008. Data were collected retrospectively by reviewing the maternal and neonatal medical records.
Results: The study population consisted of 54 cases with prenatally diagnosed omphalocele. In all, 15 fetuses were live-born, 29 were terminated, four died in utero, and six were lost to follow-up. Associated anomalies were found in 72.9% (35/48). Abnormal karyotype was found in 33.3% (16/48). In the live births, associated major anomalies were present in 46.7% (7/15) and were associated with increased neonatal morbidity. The rate of severe neonatal morbidity was 53.3% (8/15). In one case, death followed prolonged hospitalization with complications related to associated anomalies. The neonatal mortality rate was 6.7% (1/15) with no postoperative deaths.
Conclusion: In this study, the neonatal mortality rates were low in the absence of associated anomalies or genetic defects. The results emphasize the importance of identifying both those fetuses with a potentially positive prognosis and favorable outcome and those which are likely to have a fatal outcome.
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KEYWORD
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Omphalocele, Prenatal diagnosis, Associated anomalies, Prognosis
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